Massive (>10cm) HCC
Conditions
Interventions
Experimental group:Stage-wise ACE HAIC systemic treatment under CBCT guidance (TKI ICI)
Sponsors
Henan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 80 years old, with no gender restrictions; 2.Newly diagnosed patients who are too old, have insufficient residual liver, or are unwilling to undergo surgical resection; or patients who have experienced a first recurrence after achieving a cure through surgery or ablation; 3.Diagnosed with HCC based on histopathology or the "Diagnosis and Treatment Guidelines for Primary Liver Cancer (2024 Edition) in China"; 4.Massive HCC (>=10 cm), which may be accompanied by sub-nodules (total number of tumors = 3.0×10^9/L, PLT >= 50×10^9/L, Hb >= 70g/L; serum creatinine <= 1.5×ULN (upper limit of normal); ALT <= 5.0×ULN, AST <= 5.0×ULN.
Exclusion criteria
Exclusion criteria: 1.A second or more primary malignant tumors; 2.Hepatic artery-venous fistula or hepatic artery-portal vein fistula (central type); 3.Diffuse HCC, main portal vein invasion, or extrahepatic metastatic lesions; 4.Severe coagulation, cardiopulmonary or other functional disorders; 5.Active hepatitis or severe infection that cannot be corrected; 6.Cachexia or multiple organ failure; 7.Allergic to chemotherapy drugs; 8.Uncontrollable neurological, mental disorders or mental illness, poor compliance, and inability to cooperate and describe treatment responses; 9.Pregnant or lactating women; 10.Contraindications for hepatic artery procedures; 11.Uncontrolled active hepatitis; 12.Investigator deems the patient unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival, PFS;Objective response rate,ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event, AE;Surgical conversion rate;Disease control rate,DCR;Overall survival,OS; | — |
Countries
China
Contacts
Public ContactXiao Jincheng
Henan Cancer Hospital
Outcome results
None listed