Subthreshold Depression
Conditions
Interventions
Intervention group:Five times a week of aerobic exercise for 6 consecutive weeks, with each session involving brisk walking at a speed of 2.5 miles per hour for 30-40 minutes(the exercise duration wil
Control group:Subjects maintain their original living habits without any exercise intervention
Sponsors
Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Assessment using the Beck Depression Inventory-II (BDI-II), with scores exceeding the cut-off value; (2) Score of 8-20 points on the 24-item Hamilton Depression Rating Scale (3) Must meet 2-4 symptoms required for the diagnosis of Major Depressive Disorder as clearly specified in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), including anhedonia/loss of interest, marked fatigue or decreased energy, psychomotor agitation or retardation, feelings of worthlessness or guilt, sleep disturbance, impaired concentration, decreased appetite and weight loss, loss of libido, and recurrent thoughts of suicide. (4) Age: Patients with depression and healthy controls aged 18–40 years, right-handed, and native Chinese speakers; (5) Sedentary lifestyle (not meeting the recommended physical activity level, i.e., exercising less than 3 days per week or less than 20 minutes per day); (6) Written informed consent obtained from patients; (7) Educational background of junior high school or above, or at least 6 years of education; (8) Normal visual acuity or normal corrected visual acuity
Exclusion criteria
Exclusion criteria: (1) Other Axis I diagnoses (Note: Axis I diagnosis is a diagnostic category in the Diagnostic and Statistical Manual of Mental Disorders (DSM), which covers various mental disorders); (2) Substance abuse or alcohol abuse; (3) Cognitive impairment, defined as a score below 24 on the Mini-Mental State Examination (MMSE); (4) Unstable diabetes mellitus; (5) Coagulation disorders (except for medically approved special cases); (6) Severe and unstable asthma; (7) History of heart defects or cardiovascular diseases; (8) Any medical condition that prohibits participation in sports or physical activity; behavioral disorders and/or negative attitudes toward group activities; (9) Evidence of acute suicide risk (10) Pndergo electroconvulsive therapy (11) Blood-borne diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale;Beck Depression Inventory; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-6;Interleukin-10;5-Hydroxytryptamine;glucocorticoid;Brain-Derived Neurotrophic Factor;cortisol;gut microbiota; | — |
Countries
China
Contacts
Public ContactYuan Kai
Peking University Sixth Hospital/ Shandong First Medical University
Outcome results
None listed