Chronic hepatitis B
Conditions
Interventions
Patients with positive HBsAg:None
Healthy control group:None
Sponsors
The Affiliated Hospital of Guilin Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for the Chronic hepatitis B group: (1) aged 18-65 years, regardless of gender; (2) diagnosed with chronic hepatitis B according to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B; (3) no history of other viral hepatitis (e.g., HCV or HDV) or liver cirrhosis/cancer; (4) voluntary signing of the informed consent form. 2.Inclusion criteria for the control group: (1) aged 18-65 years, regardless of gender; (2) patients definitively ruled out for chronic hepatitis B diagnosis according to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (e.g., HBsAg negative, undetectable HBV DNA, normal liver function and no evidence of hepatitis activity); (3) no history of other viral hepatitis (e.g., HCV or HDV) or liver cirrhosis/cancer; (4) voluntary signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for the Chronic hepatitis B group: (1) received antiviral therapy or immunomodulatory therapy within the past 6 months; (2) presence of severe comorbidities (e.g., uncontrolled heart failure, renal failure, autoimmune diseases); (3) poor compliance (e.g., inability to complete follow-up or refusal to sign informed consent). 2.Exclusion criteria for the healthy control group: (1) presence of other viral hepatitis (e.g., HCV or HDV) or HIV infection; (2) comorbid metabolic diseases (e.g., diabetes, fatty liver disease) or severe cardiac or renal dysfunction; (3) pregnancy or lactation in female subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression status: NAAA, MMS19, XPD, XPB, etc.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum PEA content; | — |
Countries
China
Contacts
Public ContactYong Zhang
The Affiliated Hospital of Guilin Medical College
Outcome results
None listed