Pneumonia Caused by Carbapenem-Resistant Gram-Negative Bacteria
Conditions
Interventions
Experimental group:Vibrating mesh nebulized inhalation of polymyxin B (combined with intravenous drip) 25 mg + 5 mL sterile water for injection, once every 12 hours
Control group:Jet nebulized inhalation of polymyxin B (combined with intravenous drip) 25 mg + 5 mL sterile water for injection, once every 12 hours
Sponsors
Union Hospital, Fujian Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for pneumonia specified by the Chinese Medical Association's Society of Respiratory Diseases; 2. CR-GNB is detected in sputum culture and is sensitive to PMB; 3. PMB aerosol inhalation combined with intravenous infusion is used for >=3 days; 4. There is an artificial airway.
Exclusion criteria
Exclusion criteria: 1. Infection with Gram-positive bacteria, viruses, fungi, or infections from other parts of the body other than the lungs; 2. Patients in a dying state; 3. Patients with severe liver and kidney dysfunction; 4. Incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall clinical efficacy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak and trough concentrations of polymyxin B in epithelial lining fluid (ELF);Bacterial eradication rate;28-day survival rate;Incidence of nephrotoxicity; | — |
Countries
China
Contacts
Public ContactLili Zhou
Union Hospital, Fujian Medical University
Outcome results
None listed