neonatal respiratory distress syndrome
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Newborns who had their umbilical cord tied at birth and were within 28 days of age, meeting the diagnostic criteria for respiratory distress syndrome, regardless of gender; (2) Require non-invasive ventilator-assisted breathing (nasal continuous positive airway pressure ventilation); (3) The parents of the children have given informed consent and signed the document.
Exclusion criteria
Exclusion criteria: (1) History of neonatal asphyxia at birth: 1) There were high-risk factors that could lead to asphyxia before birth; 2) 1 or 5-minute Apgar score <= 7, and no effective spontaneous breathing had been established; 3) Umbilical artery blood pH < 7.15; 4) Other causes causing low Apgar score were excluded. The above 2) - 4) are necessary conditions, and 1) is a reference condition; (2) Respiratory failure caused by other related diseases except the respiratory system (central respiratory failure, cardiogenic respiratory failure, etc.), thoracic deformity, respiratory muscle paralysis, etc.; (3) Head B-ultrasound or cranial MRI examination indicates evidence of intracranial hemorrhage, cerebral infarction, periventricular leukomalacia or brain malformations; (4) Neonates with persistent hypoglycemia or neonates with hyperglycemia who received insulin intervention; (5) Those who cannot tolerate changes in body position: persistent hypotension, trauma, fracture, or unstable hemodynamics when in the prone position.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days of non-invasive respiratory support; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of days receiving oxygen therapy in the hospital;transcutaneous oxygen saturation;respiratory rate;The incidence of apnea;The incidence of pneumothorax;heart rate;blood pressure;The incidence of abdominal distension;The incidence of vomiting;Duration of gastric tube insertion;The time for achieving full enteral feeding;Number of severe complications;Incidence of pressure injuries;The incidence of nasal catheter detachment;The incidence of gastric tube detachment;length of stay;Rate of weight gain; | — |
Countries
China
Contacts
Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University