Bidirectional endoscopy in the elderly
Conditions
Interventions
Oliceridine and propofol group:0.02mg/kg oliceridine+2mg/kg propofol ,additional intraoperative propofol 0.5mg/kg as needed.
Oliceridine and ciprofol group:0.02mg/kg oliceridine+0.4mg/kg ciprofol ,additional intraoperative ciprofol 0.1mg/kg as needed.
Saline placebo and propofol group:Saline placebo+2mg/kg propofol ,additional intraoperative propofol 0.5mg/kg as needed.
Saline placebo and ciprofol group:Saline placebo+0.4mg/kg ciprofol ,additional intraoperative ciprofol 0.1mg/kg as needed.
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital)
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Able to fully understand the study and voluntarily agree to participate; written informed consent obtained from the participant (or a legally authorized representative, if applicable). 2. ASA class II -III. 3. Age 65-80 years. 4. 18.5kg/m^2<=BMI<28kg/m^2. 5. Elective, same-visit bidirectional endoscopy performed consecutively under a single sedation session (same-session EGD and colonoscopy).
Exclusion criteria
Exclusion criteria: 1. Language, visual, or hearing impairment that interferes with communication. 2. Mental illness, psychological disorders, or neurological disease. 3. History of cerebrovascular accident, myocardial infarction, or unstable angina within the past 3 months; severe hepatic or renal dysfunction. 4. Known allergy or contraindication to propofol, ciprofol, opioids, or their components. 5. Recent use of analgesic, sedative, or hypnotic drugs, or a history of alcohol/substance abuse. 6. Participation in another clinical drug trial within the past 3 months. 7. Anticipated examination duration >30 minutes. 8. Determined by the investigator to be unsuitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to awakening; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation success rate;Induction time;Procedure time;Time to discharge;Study drug utilization;Hemodynamic parameters;Use of hemodynamic support and antagonistic agents;Satisfaction; | — |
Countries
China
Contacts
Public ContactChun Yang
Jiangsu Province People's Hospital
Outcome results
None listed