Patients undergoing laparoscopic surgery under general anesthesia with tracheal intubation
Conditions
Interventions
Group O:2mg oxelidine is configured to 5ml
Group S:0.9% saline 5ml
Sponsors
The First People's Hospital of Guiyang City
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with ASA 1-3 grade, aged over 18 years, and requiring laparoscopic surgery under general anesthesia with tracheal intubation.
Exclusion criteria
Exclusion criteria: There are absolute or relative contraindications for general anesthesia; combined with severe heart, liver, or kidney dysfunction; having a history of mental illness or abuse of opioid analgesics; having high-risk factors for aspiration; diagnosed with chronic obstructive pulmonary disease or asthma; having a recent history of respiratory infection; having cognitive dysfunction; body mass index (BMI) > 35 kg/m^2; expected difficulty in tracheal intubation; expected surgical duration exceeding 3 hours; intraoperative blood loss exceeding 20%; patients who need mechanical ventilation support after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patients whose tube removal quality score was greater than 2 during tube removal; | — |
Secondary
| Measure | Time frame |
|---|---|
| The intraoperative dosage of rocuronium bromide;The intraoperative dosage of sufentanil;Surgical duration;Resuscitation room stay time;The placement status of the drainage tube and the urinary catheter;The "eye-opening time" is defined as the period from when sevoflurane administration stops until the subject can open their eyes in response to verbal stimulation.;The extubation time is defined as the period of time between the cessation of sevoflurane administration and the removal of the endotracheal tube.;Heart rate;Systolic blood pressure;Diastolic blood pressure;Arterial pressure;The highest score for sedation during the PACU period after extubation;The number of patients with a VAS pain score of 4 or higher in the resuscitation room after extubation;The number and dosage of cardiovascular active drugs, tramadol and metoclopramide used after the administration of Oseliadin;The lowest respiratory rate during the PACU period after extubation;Complications after extubation (including nausea and vomiting score, hypoxemia, apnea, aspiration, severe straining, chills, dizziness, tracheal and laryngeal spasm, extubation failure, re-intubation rate, sore throat and hoarseness);Postoperative 24-hour recovery quality (assessed using the Quality of Life Questionnaire (QoR-15));Postoperative 24-hour pain VAS score;The maximum VAS score for pain within 24 hours after the operation;The number of patients using rescue analgesics and antiemetics in the hospital ward; | — |
Countries
China
Contacts
Public ContactZhang Jun
The First People's Hospital of Guiyang City
Outcome results
None listed