Anesthesia
Conditions
Interventions
Male group:Sufentanil+Cipepofol
Female group:Sufentanil+Cipepofol
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 65 years; 2. ASA Classification I-III; 3. Patients scheduled for elective surgery under general anesthesia, with plans to send to the recovery room after surgery.
Exclusion criteria
Exclusion criteria: 1.Patients with difficult airways; 2.patients with opioid allergy or abuse; 3.patients with severe hypertension; 4.patients with severe arrhythmias (sinus bradycardia, ventricular rate <50 beats per minute; second-degree or higher atrioventricular block or ventricular block; other arrhythmias with a high risk of sinus arrest, such as sick sinus syndrome (SSS)) ; 5. patients with severe heart failure (NYHA) class III or higher; 6.patients with impaired liver or kidney function; 7.patients with pathological obesity; 8.women who are pregnant, in labor, or breastfeeding; 9.patients whose preoperative mental status cannot be independently or accurately determined; 10. patients with a history of psychotropic drug use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50/ED95 when BIS <= 60 after Cipepofol injection combinated with sufentanil ; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIBP, heart rate, SpO2,BIS;The total amount of vasoactive drug usage;Total amount of anesthetic drugs during surgery;The time from anesthesia induction to LOC and BIS <= 60, the time from discontinuation to recovery, the duration of surgery, and the duration of anesthesia;Patient comfort level; | — |
Countries
China
Contacts
Public ContactGuan Xuehai
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed