This study focused on the comorbidity population of acute ischemic or hemorrhagic stroke and obstructive sleep apnea (OSA). The core of the study focuses on two core syndromes that are caused or exacerbated by this comorbid state: post-stroke cognitive impairment (PSCI), which manifests as difficulty concentrating, memory loss, impaired executive function, and slowed information processing
Conditions
Interventions
Control group:Conventional treatment
Treatment group:Continuous positive airway pressure
Sponsors
Northwestern University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Acute cerebral infarction diagnosed by CT or MRI; 2. Meet the diagnostic criteria of the International Classification of Sleep Disorders-third edition (ICSD-3) and meet the diagnostic criteria for OSA in adults: the following 1) 2) 3) are required. (1) At least one of the following manifestations: 1) complaints of drowsiness, non-restorative sleep, fatigue or insomnia; 2) waking up from sleep due to holding breath or wheezing; 3) Residents in the same dormitory or other witnesses report habitual snoring, interruption of breathing, or both during sleep; 4) Confirmed hypertension, mood disorders, cognitive impairment, coronary heart disease, cerebrovascular disease, congestive heart failure, atrial fibrillation, or type 2 diabetes. (2) PSG or out-of-center sleep test (OCST) confirmed that respiratory events occurred during >= 5 times/hour during the monitoring period, including obstructive apnea, mixed apnea, hypopnea, and respiratory effort-related awakenings. (3) PSG or OCST confirmed that respiratory events occurred during >= 15 times/hour during monitoring, including obstructive apnea, mixed apnea, hypopnea, and RERAs, and patients with an AHI >= 20/h. 3. Age 18-80 years old; 4. within 2 weeks after the onset of stroke; 5. Clear consciousness and able to complete simple instructions; 6. Patients who provide informed consent.
Exclusion criteria
Exclusion criteria: 1. History of traumatic brain injury or brain tumor; 2. Diagnosis of mild obstructive sleep apnea (OSA) or central sleep apnea or mixed sleep apnea; 3. Baseline oxygen saturation < 95%; 4. Acute or chronic cardiopulmonary disease affecting lung function; 5. Presence of neuromuscular diseases (such as amyotrophic lateral sclerosis and muscle weakness); 6. Patients with severe dysfunction of other important organs and unstable condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSG detection;NfL and GFAP levels;Cognitive and functional assessments; | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic information collection; | — |
Countries
China
Contacts
Public ContactZhao Rongjian
Northwestern University First Hospital
Outcome results
None listed