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Effect of the Ligament of Marshall Excision During Minimally Invasive Cardiac Surgery–Coronary Artery Bypass Grafting (MICS-CABG) on the Prevention of Postoperative New-Onset Atrial Fibrillation: A Single-Center, Prospective, Triple-Blind (Participant, Outcome Assessor, and Statistician), Randomized Controlled Trial

Effect of the Ligament of Marshall Excision During Minimally Invasive Cardiac Surgery–Coronary Artery Bypass Grafting (MICS-CABG) on the Prevention of Postoperative New-Onset Atrial Fibrillation: A Single-Center, Prospective, Triple-Blind (Participant, Outcome Assessor, and Statistician), Randomized Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500110913
Enrollment
Unknown
Registered
2025-10-22
Start date
2025-10-23
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative New-Onset Atrial Fibrillation

Interventions

Intervention Group:Excision of the Ligament of Marshall During MICS-CABG
Control Group:Standard MICS-CABG Without Excision of the Ligament of Marshall

Sponsors

Peking University Third Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Age between 30 and 80 years; 2.Diagnosed with coronary artery disease meeting the surgical indications for coronary revascularization. Scheduled to undergo minimally invasive cardiac surgery–coronary artery bypass grafting (MICS-CABG).

Exclusion criteria

Exclusion criteria: 1. Patients with preoperative haemodynamic instability requiring emergency surgery; 2. Pre-operative history of paroxysmal atrial fibrillation or persistent atrial fibrillation; 3. Patients with preoperative implanted pacemakers; 4. Patients with EF 60mm, left ventricular wall tumour or severe arrhythmia, who are prone to haemodynamic instability during surgery; 5. Combined mitral stenosis or closure insufficiency of moderate degree or above; 6. Concurrent valve surgery or other intracardiac corrective surgery; 7. Patients with previous renal insufficiency requiring haemodialysis; 8. Patients with perioperative IABP or ECMO circulatory assistance; 9. Preoperative administration of antiarrhythmic drugs other than beta-blockers, such as propafenone and amiodarone; 10. Previous cardiac surgery or thoracic surgery; 11. Poor pulmonary function, preoperative resting unoxygenated state of arterial blood gas analysis oxygen partial pressure <60mmHg.

Design outcomes

Primary

MeasureTime frame
Incidence of Postoperative New-Onset Atrial Fibrillation (POAF);—

Secondary

MeasureTime frame
Frequency and Duration of Atrial Fibrillation or Flutter Episodes;Number and percentage of patients requiring antiarrhythmic therapy (Vaughan Williams Class I or III agents) or electrical cardioversion for rhythm control;Postoperative Length of Hospital Stay;Duration of Mechanical Ventilation;Reoperation for Bleeding;—

Countries

China

Contacts

Public ContactYunpeng Ling

Peking University Third Hospital

micsling@pku.edu.cn+86 156 1196 3466

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 3, 2026