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Study on the mechanism of FadA, a virulence gene of Clostridium periodontal disease, involved in the regulation of esophageal cancer stem cells

Study on the mechanism of FadA, a virulence gene of Clostridium periodontal disease, involved in the regulation of esophageal cancer stem cells

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110908
Enrollment
Unknown
Registered
2025-10-22
Start date
2025-11-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ESCC

Interventions

Healthy control group:None
Esophageal cancer case group:No

Sponsors

Huai'an First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Case population: Patients with primary esophageal squamous cell carcinoma diagnosed by pathology or endoscopy, and Han residents who have lived in high-risk areas for more than 20 years. Control population: According to the 1:1 matching principle, select Han residents of the same gender, with an age difference of +/- 5 years, and local permanent residents as the control population. Informed consent form content, and agree to participate

Exclusion criteria

Exclusion criteria: 1. Patients who have received chemotherapy or radiotherapy before sampling. 2. Pregnant or lactating patients.

Design outcomes

Primary

MeasureTime frame
Urinary nitrosamine levels;Serum Metabolome;Oral Microbiota;—

Secondary

MeasureTime frame
circRNA expression levels in cancerous tissue;—

Countries

China

Contacts

Public ContactZhang zhenzhong

Huai'an First People's Hospital

smjun2015@seu.edu.cn+86 159 8764 0914

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026