Postoperative Nausea and Vomiting
Conditions
Interventions
experimental group:During anesthesia induction, 10mg dexamethasone was intravenously injected, 8mg ondansetron was intravenously injected 30 minutes before the end of the surgery, and 20mg diphenhydra
control group:During anesthesia induction, 10mg dexamethasone was intravenously injected, and 8mg ondansetron was intravenously injected 30 minutes before the end of the surgery.
Sponsors
Anesthesia and Surgery Center of West China Hospital Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18-75 years old; 2. ASAI-III level; 3. Selective thoracoscopic lobectomy (including thoracoscopic wedge resection, thoracoscopic segmentectomy, thoracoscopic lobectomy); 4. Voluntary use of intravenous analgesia pump; 5. Apfel risk factors>=3; 6. The subjects have a clear understanding and voluntarily participate in this study, can sign an informed consent form, and voluntarily follow the research process.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for the use of dexamethasone, ondansetron, and diphenhydramine; 2. Preoperative use of antiemetic drugs; 3. Language communication barriers; 4. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PONV within 24 hours after surgery;The severity of nausea, retching, and vomiting within 0-24 and 25-72 hours after surgery;Use of emergency antiemetic drugs within 0-24h and 25-72h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of nausea, retching, and vomiting within 0-24 and 25-72 hours after surgery;Pain intensity during rest and coughing at 24h and 72h postoperatively;Postoperative hospitalization duration;Total hospitalization expenses;Incidence of adverse drug reactions; | — |
Countries
China
Contacts
Public ContactLiu Fei
Anesthesia and Surgery Center of West China Hospital Sichuan University
Outcome results
None listed