Sepsis
Conditions
Interventions
CRRT group:None
Non-CRRT group:None
Sponsors
Beijing Shijitan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 to 85 years old, gender unrestricted; 2. Signed informed consent form; 3. Met the diagnostic criteria of sepsis 3.0; 4. Confirmed pathogen as CRAB or CRE infection; 5. Received eravacycline treatment for at least 120 hours (5 days).
Exclusion criteria
Exclusion criteria: 1. Patients with a history of allergy to tetracycline drugs or to excipients; 2. Patients with insensitivity to eravacycline (MIC > ERV breakpoint); 3. Patients with a single pathogen of Pseudomonas aeruginosa; 4. Patients with bloodstream infection; 5. Patients with an expected survival time less than the study period or a high risk of loss to follow-up; 6. Patients with concurrent pregnancy, mental illness or cognitive impairment; 7. Patients with severe liver failure (Child-pugh C grade) or hyperbilirubinemia (bilirubin level higher than 3mg/dl); 8. Patients concurrently using strong CYP3A inducers, such as rifampicin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The clearance rate of eravacycline by CRRT (peak and trough concentrations of eravacycline in the two groups of patients); | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbial clearance efficiency;Clinical effectiveness; | — |
Countries
China
Contacts
Public ContactLi Hongliang
Beijing Shijitan Hospital, Capital Medical University
Outcome results
None listed