hypotension after general anesthesia induction
Conditions
Interventions
The esketamine group:Induction of anesthesia was achieved through intravenous injection of etomidate at a dose of 0.2mg/kg and esketamine at a dose of 0.2mg/kg.
The control group:Induction of anesthesia was achieved through intravenous injection of etomidate at a dose of 0.2mg/kg and normal saline.
Sponsors
The Fourth Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
75 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. patients scheduled for elective percutaneous vertebroplasty under general anaesthesia with tracheal intubation; 2. aged 75-90 years; 3. ASA II-III; 4. BMI 18-30 kg/m^2; 5. No history of cognitive impairment.
Exclusion criteria
Exclusion criteria: 1. hypersensitivity to any of the drugs used in the study; 2. uncontrolled hypertension (blood pressure > 180/100 mmHg at rest); 3. previous history of aneurysm/arteriovenous malformation; 4. Hyperthyroidism; 5. Severe cardiac disease (NYHA class III or IV; untreated or unstable ischaemic heart disease; history of severe aortic or mitral valve disease); 6. Severe hepatic impairment (Child-Pugh Class C); 7. severe renal impairment (undergoing renal replacement therapy); 8. history of previous psychiatric illness; 9. MAP <70 mmHg before induction of anaesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve (AUC) of the change in mean arterial pressure (MAP) from baseline within 15 minutes after general anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of hypotension within 15 minutes after general anesthesia induction;Maximum mean arterial pressure and heart rate;Minimum mean arterial pressure and heart rate;Cumulative number of phenylephrine;Cumulative dosage of phenylephrine;Time of disappearance of eyelash reflex ;Time of extubation;Recovery room stay time;Postoperative recovery quality score of the first day;Delirium; | — |
Countries
China
Contacts
Public ContactChen Mo
The Fourth Affiliated Hospital of Soochow University
Outcome results
None listed