?Invasively ventilated patients with acute respiratory distress syndrome
Conditions
Interventions
Study Group:None
Control Group:None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Study Group: 1. Age between 18 and 80 years; 2. Diagnosis of ARDS according to the Berlin Definition; 3. Requiring invasive mechanical ventilation due to their clinical condition; 4. Provision of signed informed consent by the patient or their legal surrogate; Control Group: 1. Age between 18 and 80 years; 2. Scheduled to undergo non-thoracic surgery requiring general anesthesia with endotracheal intubation and mechanical ventilation; 3. No preoperative respiratory symptoms and a normal preoperative chest radiograph; 4. Postoperative arterial blood gas with a PO2/FiO2 ratio > 400 mmHg; 5. Provision of signed informed consent by the patient or their legal surrogate;
Exclusion criteria
Exclusion criteria: 1. Age 80 years; 2. Body Mass Index (BMI) 30 kg/m^2; 3. Pregnancy or lactation; 4. Received invasive mechanical ventilation for more than 48 hours within the past 7 days, or those receiving ventilation via a tracheostomy; 5. Severe hemodynamic instability, severe heart failure, or acute coronary syndrome; 6. Patients receiving Extracorporeal Membrane Oxygenation (ECMO) therapy; 7. Presence of pneumothorax, bronchopleural fistula, pneumomediastinum, massive pleural effusion, diaphragmatic hernia, chest wall deformity, significant pulmonary bullae, or within 2 weeks post-lobectomy or other pulmonary surgery; 8. Pre-existing chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, interstitial lung disease, pulmonary embolism, right heart failure, pulmonary hypertension, or severe cardiac arrhythmias; 9. Managed with non-invasive ventilation or high-flow nasal cannula oxygen therapy at the time of screening; 10. Severe neurological disorders, such as intracranial hypertension or neuromuscular diseases; 11. Patients previously enrolled in this study who are re-admitted to the ICU, or those currently participating in another clinical trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interframe Pixel Change Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay;Maximum inspiratory-expiratory density difference;Duration of mechanical ventilation;28-day mortality in patients with ARDS; | — |
Countries
China
Contacts
Public ContactYou Shang
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed