Patients with ovarian insufficiency
Conditions
Interventions
Sponsors
Jingdezhen Second People’s Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Women aged 18–40 years diagnosed with premature ovarian insufficiency (POI), with normal body weight and height. Diagnosis of POI must meet at least two of the following criteria: Baseline FSH level > 10 IU/L; Oligomenorrhea or amenorrhea for at least two consecutive cycles (interval > 4 weeks); Fluctuating decline in estrogen levels; Anti-Müllerian hormone (AMH) < 1.0–1.2 ng/mL; Basal antral follicle count (AFC) < 5–7 on ultrasound. 2.General condition good; no severe dysfunction of the heart, lungs, kidneys, or liver; no metabolic diseases. 3.No use of antibiotics, other medications, or probiotics within 3 months prior to enrollment after treatment completion.
Exclusion criteria
Exclusion criteria: 1.Patients who do not meet the above inclusion criteria; 2.Severe active viral or bacterial infections that are not adequately controlled; 3.Any severe or chronic conditions that, in the opinion of the investigator, may interfere with treatment, follow-up, or assessment. This includes but is not limited to: Uncontrolled clinically significant neurological or psychiatric disorders; Immunomodulatory diseases; Metabolic disorders; Infectious diseases. 4.Patients deemed by the clinician as unsuitable for probiotic adjunctive therapy after evaluation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sex hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| gut microbiota; | — |
Countries
China
Contacts
Public ContactXiaohui Wang
Jingdezhen Second People’s Hospital
Outcome results
None listed