Post-induction hypotension
Conditions
Interventions
Test group:During induction, the patient received ciprofol (0.3mg/kg) until loss of consciousness.
Control group:During induction, the patient was administered propofol (1.5mg/kg) until loss of consciousness.
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
75 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. To undergo elective non-cardiac surgery; 2. Gender not limited, age >= 75 years old; 3. Require tracheal intubation for general anesthesia induction; 4. ASA I-III grade; 5. Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. BMI >= 30 kg·m² ; 2. History of brain or thoracic, abdominal aortic aneurysm ; 3. Allergic to any drugs administered in the study ; 4. History of severe liver dysfunction, i.e., Child-Pugh C grade ; 5. Chronic kidney disease requiring dialysis treatment ; 6. Congestive heart failure, namely New York Heart Association classification III or IV ; 7. Untreated or unstable ischemic heart disease ; 8. History of severe aortic or mitral valve disease ; 9. History of multiple premature ventricular contractions, multiple premature atrial contractions, and atrial fibrillation ; 10. Use of antidepressants or antipsychotic drugs ; 11. Systolic blood pressure >= 200 mm Hg and/or diastolic blood pressure >= 120 mm Hg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension after induction (GAIH); | — |
Secondary
| Measure | Time frame |
|---|---|
| The maximum value of MAP after tracheal intubation;The incidence of a MAP decrease of more than 20%;The incidence of a MAP decrease of more than 30%;The minimum heart rate after loss of consciousness induced by anesthesia;The time from the start of anesthesia to the loss of consciousness and the disappearance of eyelid reflexes;The total amount of anesthesia-inducing drugs (propofol, cyclopofol, alfentanil);The administration frequency and total dosage of vasoactive drugs;The incidence of atropine injection;The incidence of injection pain was evaluated using the four-point scale (0, no pain;) 1. Mild pain; 2. Moderate pain; 3. Severe pain;Choking cough during the induction period and postoperative nausea and vomiting; | — |
Countries
china
Contacts
Public ContactHan Xiaodan
Zhongshan Hospital, Fudan University
Outcome results
None listed