Insomnia
Conditions
Interventions
Control group:Sham repeated transcranial magnetic stimulation
Trial group:Repeated transcranial magnetic stimulation
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 24 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 24 years (inclusive), regardless of gender; 2. Meets the DSM-5 diagnostic criteria for insomnia; 3. Pittsburgh Sleep Quality Index (PSQI) score greater than 7 and less than 15, and able to comply with fMRI scanning requirements; 4. Good compliance, capable of understanding and voluntarily accepting the study protocol, with informed consent signed.
Exclusion criteria
Exclusion criteria: 1. Presence of severe somatic diseases or conditions that may affect the central nervous system (e.g., systemic diseases requiring corticosteroid use, malignancy, syphilis). 2. History of intracranial diseases, head trauma, alcohol abuse, abnormal electroencephalogram (EEG), evidence of structural brain abnormalities on MRI, or a family history of epilepsy. 3. Presence of comorbid conditions requiring priority treatment (e.g., suicidal ideation or severe mental disorders) or substance abuse (e.g., alcohol, hypnotic drugs); or uncontrolled conditions that affect sleep or require urgent intervention (e.g., obstructive sleep apnea requiring continuous positive airway pressure therapy). 4. Contraindications to MRI scanning or transcranial magnetic stimulation, such as the presence of metallic or electronic implants (e.g., intracranial metal objects, cochlear implants, cardiac pacemakers, stents), or claustrophobia. 5. Current pregnancy, lactation, or planning a pregnancy during the trial period. 6. Other circumstances deemed by the investigator as unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatigue Scale-14 score;Insomnia Daytime Symptoms Inventory Questionnaire-14 score;Hamilton Depression Scale score;Hamilton Anxiety Scale score;Psychomotor Vigilance Task score;Brain MRI;Small-molecule metabolic biomarkers (changes in plasma histidine and valine concentrations);Epworth Sleepiness Scale score; | — |
Countries
China
Contacts
Public ContactCai Min
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed