Skip to content

Single-cell combined spatial transcriptome gene sequencing was used to analyze the differences in the tumor microenvironment of primary hepatocellular carcinoma with or without liver cirrhosis

Single-cell combined spatial transcriptome gene sequencing was used to analyze the differences in the tumor microenvironment of primary hepatocellular carcinoma with or without liver cirrhosis

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110834
Enrollment
Unknown
Registered
2025-10-21
Start date
2023-01-25
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver fibrosis,Liver cancer

Interventions

Primary hepatocellular carcinoma with liver cirrhosis:None
primary hepatocellular carcinoma without liver cirrhosis:None

Sponsors

Henan Provincial People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age: >= 18 years old; 2. Hepatocellular carcinoma: First diagnosis, no history of anti-cancer treatment (chemotherapy, interventional therapy, etc.), no metastasis, underwent radical surgical resection, and postoperative pathological examination of the cancer tissue confirmed primary hepatocellular carcinoma.; 3. Chronic hepatitis B: HBsAg (+), HBV DNA < 500 um/ml (regardless of whether antiviral drugs are taken or not); 4. No other liver diseases: such as chronic hepatitis C, non-alcoholic fatty liver disease, autoimmune liver disease, metabolic liver disease (hepatolenticular degeneration), etc. 5. No history of other chronic diseases: such as history of other malignant tumors, autoimmune diseases, hypertension, diabetes, hyperlipidemia, severe heart, lung, kidney, and blood diseases, etc. 6. History of alcohol consumption: None; 7. History of smoking: None/occasional; 8. Tumor markers: Elevated AFP, normal CEA and CA19;

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

MeasureTime frame
Cell type;

Secondary

MeasureTime frame
Organizational structure;

Countries

China

Contacts

Public ContactLan Ling

Henan Provincial People’s Hospital

lanling95@163.com+86 131 0059 3646

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026