Adolescent depression
Conditions
Interventions
Adolescent depression with non-suicidal self-injury group:None
Adolescent depression without non-suicidal self-injury group:None
Healthy control group:None
Sponsors
The Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: Adolescents aged 10 to 19 years; 2. Informed Consent: Both the participant and their legal guardian fully understand the study content, voluntarily participate, and sign a written informed consent form; 3. Physical Examination: Major vital signs (such as blood pressure, heart rate) and routine biochemical tests show no clinically significant abnormalities; 4. Group-specific Inclusion Criteria: (1) Depression with NSSI Group: 1) Meets the diagnostic criteria for depressive disorders in the 11th edition of the International Classification of Diseases (ICD-11) or the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 2) Has had clear, repeated non-suicidal self-injury behaviors (>=1 time/month) in the 6 months prior to enrollment (confirmed by at least two psychiatrists of attending physician or higher title through clinical interview and OSI scale assessment); (2) Pure Depression Group (without NSSI): 1) Meets the diagnostic criteria for depressive disorders in ICD-11 or DSM-5; 2) Has no lifetime history of non-suicidal self-injury (confirmed by clinical interview and OSI scale); (3) Healthy Control Group: 1) No history of any psychiatric disorder diagnosed according to ICD-11/DSM-5; 2) No self-injury behavior or suicidal ideation history; 3) Gender and age roughly match those of the case groups.
Exclusion criteria
Exclusion criteria: 1. Comorbidity with other severe mental disorders: such as schizophrenia, bipolar disorder, autism spectrum disorder, intellectual disability, substance use disorder, etc.; 2. Organic diseases: having severe or unstable physical diseases (such as epilepsy, brain injury, autoimmune diseases, cancer, etc.) and neurological diseases; 3. Abnormal laboratory indicators: clinically significant abnormalities in blood routine, liver and kidney function tests, etc., which may affect research assessment or participant safety; 4. Special medication history: long-term use of immunosuppressants, glucocorticoids, or other drugs that may seriously affect neuroendocrine function within 3 months before enrollment; 5. Other factors: women who are pregnant or breastfeeding; presence of serious suicide risk (requiring immediate intervention based on clinical assessment); inability to communicate effectively or complete scale assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RNA/protein expression level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical efficacy;Clinical cure rate; | — |
Countries
China
Contacts
Public ContactQingxiao Hong
The Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed