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Multi-Omics Profiling of Response Heterogeneity in Adiposity Reduction to Combined Training in Young Adults with Obesity

Multi-Omics Profiling of Response Heterogeneity in Adiposity Reduction to Combined Training in Young Adults with Obesity

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500110819
Enrollment
Unknown
Registered
2025-10-21
Start date
2025-10-30
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Combined Resistance and Aerobic Training Group:Resistance Training Protocol Weeks 1–4: Knee push-ups, standard squats, back extension, glute bridge with diagonal arm raise, and abdominal crunches (12

Sponsors

Beijing Sport University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: 1. Age: Young adults aged 18 to 30 years; 2. Body Mass Index (BMI): BMI >= 28 kg/m^2; 3. Health status: No severe cardiovascular, respiratory, neurological, or other major diseases that may impair exercise capacity; 4. Exercise capacity: Able to safely perform moderate to high-intensity aerobic and resistance exercise; 5. Informed consent: Willing and able to provide written informed consent and committed to completing all assessments and exercise interventions as required by the study; 6. No recent participation in similar studies: Has not participated in any other weight-loss or exercise intervention studies within the past three months.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women: Due to their special physiological needs, such individuals are temporarily excluded from the study. 2. Severe musculoskeletal disorders: Including but not limited to severe arthritis, history of fractures, or muscle diseases, which may impair physical mobility or increase the risk associated with exercise. 3. Severe metabolic disorders: Such as uncontrolled diabetes, hyperthyroidism, or hypothyroidism, which may affect study outcomes. 4. Mental health conditions: Severe depression, anxiety disorders, or other psychiatric illnesses that may compromise participant engagement or the effectiveness of the intervention. 5. Medication effects: Currently using medications that influence body weight, metabolism, or physical performance, such as weight-loss drugs, corticosteroids, or antidepressants. 6. Allergies or intolerance: Allergic or adverse physiological reactions to certain forms of exercise. 7. Non-compliance with study requirements: Individuals who, during initial screening, demonstrate an inability to adhere to the intervention and assessment protocols.

Design outcomes

Primary

MeasureTime frame
Body composition (whole-body skeletal muscle mass, whole-body fat mass, and whole-body bone mass, etc.);Body morphology(height, body weight, waist circumference, hip circumference, etc.);Skinfold thickness;Blood pressure;Musculoskeletal ultrasound (muscle thickness, subcutaneous fat thickness, etc.);Maximal oxygen uptake;Hepatic steatosis assessed by ultrasonography;Cardiac function;Vascular function;Blood biochemical indicators (lipid profile, blood glucose, insulin, uric acid, hemoglobin, etc.);One-Repetition Maximum;Lower-limb explosive power(vertical jump height, maximal strength, peak power, etc.);1000-meter run (male) / 800-meter run (female);Pull-ups (male) / Sit-ups (female);50-meter run;Sit-and-reach test;Standing long jump;Vital capacity;Physical Activity Readiness Questionnaire;Food Frequency Questionnaire;Eating Behaviors Assessment for Obesity;24-hour dietary recall;Pittsburgh Sleep Quality Index;In-depth interviews;Genomics profiling;Epigenomic profiling;Metabolomics profiling;

Countries

China

Contacts

Public ContactWang Yaqi

Beijing Sport University

wangyaqi@bsu.edu.cn+86 176 1084 8839

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026