Postoperative Cognitive Dysfunction
Conditions
Interventions
Esketamine group:Load 0.25mg/kg+0.25mg/kg/h pump
Control group:Equal volume 0.9% normal saline
Sponsors
Anhui No.2 Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) II to III; 2. Non-cardiac surgery under tracheal intubation general anesthesia is planned; 3. Age >=65 years old; BMI (Body Mass Index) : 18-30kg/m^2; 4. Preoperative Pittsburgh Sleep Quality Index (PSQI) >=7 points or Athens Insomnia Scale (AIS) >=6 points; 5. Patients accepted the survey with good compliance, could complete the assessment and gave informed consent to participate
Exclusion criteria
Exclusion criteria: 1. Allergies to any of the drugs used in the study; 2. The use of esketamine is contraindicated; 3. Liver and kidney dysfunction; 4. History of mental illness or use of psychotropic drugs; 5. A recent history of alcohol abuse; 6. Difficulty in verbal communication, significant hearing or visual impairment; 7. The preoperative Mini-mental State Examination (MMSE) score was <24 or the baseline cognitive assessment could not be completed
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Haemodynamics;The incidence of postoperative delirium;Blood index(IL-1ß,IL-6,TNF-a,S100-ß,HMGB1,RAGE,NfL);Hospital anxiety and depression scale,HADS;Sleep quality score;Visual analogue scale;Depth of anesthesia;Vasoactive drug;Postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactLi Tingting
Anhui Number 2 Province People's Hospital
Outcome results
None listed