Neurosurgical disorders
Conditions
Interventions
Test group:Sedation with sodium hydroxybutyrate during induction of anesthesia
Control Group:Sedation with propofol during induction of anesthesia
Sponsors
Capital University of Medical Sciences Sambo Brain Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Patients who need tracheal intubation and general anesthesia for selective neurosurgical operations; (2) American Society of Anesthesiologists (ASA) Class I-II; (3) Aged 18-60(including 18 and 60 years old) , male or female; (4) Subjects voluntarily participated in the study and signed a written informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with hypokalemia; (2) Patients with heart block and bradycardia (heart rate < 50 beats/min) ; (3) Patients with a history of asthma, epilepsy, etc. ; (4) Patients with a history of drug allergy; (5) Patients with difficult airways; (6) Patients who recently participated in another clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference between the mean arterial pressure immediately before endotracheal intubation and the baseline mean arterial pressure before induction of anesthesia was measured in all patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| General information of the patient included gender, age, height, weight, BMI, and Asa Class;Before anesthesia induction (T 0) , immediately after ciliary reflex disappeared (t 1) , immediately before endotracheal intubation (t 2) , immediately after endotracheal intubation (t 3) , 1 min after endotracheal intubation (t 4) , 3 min after endotracheal intubation (t 5) , 5 min after endotracheal intubation (t 6) , 10 min after endotracheal intubation (t 7) were recorded in each time point of NIBP, HR, SpO2, RE, SE, SV, CO, SVR.;The time from induction of anesthesia to disappearance of oral command, disappearance of eyelash reflex and entropy index (RE) < 60 were recorded.;The use of vasoactive drugs during anesthesia induction was recorded.;The occurrence of adverse reactions such as injection pain, bradycardia (heart rate < 50 bpm) , hypotension (MAP =65 mm Hg or decreased by more than 20% of the baseline value) , and hypertension (MAP increased by more than 20% of the baseline value) were recorded.;The number of cases in each group was recorded.;The occurrence of adverse reactions such as nausea and vomiting during the 24-hour postoperative follow-up was recorded.; | — |
Countries
China
Contacts
Public ContactWang Baoguo
Capital University of Medical Sciences Sambo Brain Hospital
Outcome results
None listed