Obesity
Conditions
Interventions
Trial group:Intraoperative individualized positive end-expiratory pressure (PEEP) ventilation strategy guided by driving pressure
Control group:Conventional fixed positive end-expiratory pressure (PEEP) ventilation strategy
Sponsors
Taizhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–65 years; 2. 45 kg/m^2>BMI>=28 kg/m^2; 3. American Society of Anesthesiologists (ASA) physical status classification of II–III;
Exclusion criteria
Exclusion criteria: 1. History of respiratory conditions including airway narrowing or obstruction, chronic bronchitis, bronchial asthma, COPD, or bronchiectasis; 2. Abnormal diaphragmatic function or concomitant neuromuscular disorders with relevant medication history; 3. Patients with thoracic or abdominal trauma, chronic pain, long-term opioid analgesic use, or history of psychotropic medication; 4. Patients requiring preoperative assisted ventilation; 5. Patients with severe cardiovascular disease history (e.g., significant arrhythmia, heart failure, angina pectoris, myocardial infarction); 6. Patients with allergy to any anaesthetic agent in the proposed regimen; 7. Patients who refuse or fail to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragm thickness at end-inspiration;End-expiratory diaphragm thickness;Diaphragm thickening fraction;Diaphragmatic excursion during quiet breathing;Deep breathing diaphragmatic mobility; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory mechanics parameters (including end-tidal carbon dioxide, heart rate, mean arterial pressure, oxygen saturation, airway plateau pressure, airway peak pressure, etc.);Oxygen Index (OI);Mechanical ventilation, pneumoperitoneum duration;OAA/S and NRS scores at T1 and T2;Pulmonary complications (atelectasis, pulmonary infection, hypoxemia) on postoperative day 1 and day 3;Incidence of postoperative nausea and vomiting (PONV); | — |
Countries
China
Contacts
Public ContactJiang Lin
Taizhou People's Hospital
Outcome results
None listed