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Platelet to High-Density Lipoprotein Cholesterol Ratio is Associated with One-Year All-Cause Mortality in Patients with Acute Coronary Syndrome: A Retrospective Cohort Study

Platelet to High-Density Lipoprotein Cholesterol Ratio is Associated with One-Year All-Cause Mortality in Patients with Acute Coronary Syndrome: A Retrospective Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110802
Enrollment
Unknown
Registered
2025-10-21
Start date
2025-11-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome

Interventions

Observation group:None

Sponsors

The Affiliated Hospital of Guangdong Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with acute coronary syndrome (ACS) admitted to the Affiliated Hospital of Guangdong Medical University from January 2022 to December 2023. Acute coronary syndrome includes ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina (UA). The primary diagnostic criteria are as follows: 1. Symptom Assessment: Symptoms of acute coronary syndrome (ACS) include chest pain and chest tightness, which may be accompanied by cardiogenic shock or severe arrhythmias. 2. Electrocardiogram (ECG) Examination: A 12-lead ECG is performed at initial evaluation to rapidly differentiate between ST-elevation myocardial infarction (STEMI) and non-ST-elevation ACS (NSTE-ACS), the latter encompassing NSTEMI and UA. 3. Biomarker Testing: High-sensitivity cardiac troponin (hs-cTn) is a key biomarker for diagnosing myocardial injury. According to the latest guidelines, all patients suspected of ACS should undergo hs-cTn testing. A 0-hour/1-hour or 0-hour/2-hour testing strategy is employed to monitor changes in hs-cTn levels. If hs-cTn exceeds the 99th percentile of the reference value for healthy individuals, acute myocardial infarction—either STEMI or NSTEMI—is diagnosed.

Exclusion criteria

Exclusion criteria: 1.Patients with incomplete medical records or medical orders information; 2.Patients with missing data on platelet counts and high-density lipoprotein cholesterol levels; 3.Patients who do not consent to participate in this study.

Design outcomes

Primary

MeasureTime frame
One-year all-cause mortality ;—

Secondary

MeasureTime frame
Major adverse cardiovascular and cerebrovascular events (including all-cause mortality, recurrent myocardial infarction, ischemic stroke, heart failure rehospitalization, revascularization or in-stent thrombosis of the same vessel, and malignant arrhythmia);Platelet-to-HDL Ratio;—

Countries

China

Contacts

Public ContactChen Lujun

The Affiliated Hospital of Guangdong Medical University

lijiaxinsunshine@163.com+86 158 1235 6212

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026