Postoperative gastrointestinal dysfunction
Conditions
Interventions
Observational group (Propofol + Opioid Sparing):None
Observational group (Remimazolam + Opioid Sparing ):None
Observational group (Esketamine + Opioid Sparing):None
Sponsors
First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.ASA I-III; 2. Age 18-85; 3. Undergo laparoscopic gynecological surgery under general anesthesia; 4. Sign an informed consent form for the observation study.
Exclusion criteria
Exclusion criteria: 1.Severe liver and kidney diseases (history of liver disease, bilirubin level greater than 3.0mg.dl^-1; aspartate aminotransferase Enzyme/alanine aminotransferase greater than 2.5 times the upper limit; serum creatinine level greater than 2mg.dl^-1); 2. Poor control of hypertension (multiple episodes of systolic blood pressure greater than 160mmHg in the hospital ward); 3. Poorly controlled diabetes (preoperative HbA1c level greater than 9%); 4. Benzodiazepines/GABA-A receptor agonists/inhalation anesthetics/flurbiprofen ester/isocloamide Keto intolerance or allergy; 5. Preoperative diagnosis of neuropsychiatric diseases such as anxiety disorder, bipolar disorder, depression, schizophrenia; 6. Pregnant or lactating; 7. Postoperative treatment should be transferred to ICU; 8. Severe gastrointestinal, pancreatic and biliary diseases (gastric reflux, gastric ulcer, bile reflux have been diagnosed before surgery Diseases, chronic constipation, inflammatory bowel disease, irritable bowel syndrome, etc.) and need medical intervention; 9. Satisfactory gastric antrum ultrasound images could not be obtained due to upper abdominal wound, obesity or abdominal distension before surgery; 10. It is expected that gastrointestinal surgery (intestinal resection and anastomosis, appendectomy, enterostomy, etc.) will be performed simultaneously during the operation. 11. The operation is expected to take more than 6 hours or end after 16:00 on the day of the operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastric antral contraction frequency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastric antral contraction amplitude;Gastric volume;Motility index;Total bowel sound within 3 minutes;Time to first passage of flatus;Time to first passage of formed stool;Time to first intake of solid food;Total equivalent oral morphine dose of opioid analgesics within 72 hours postoperatively, number of rescue antiemetic doses, and number of laxative doses used.;Pittsburgh Sleep Quality Index scores at 3 days postoperatively, and NRS pain scores at rest and during activity.;Length of postoperative hospital stay;Admission to ICU;Requirement for reoperation;Occurrence of other surgical complications;Ultrasound-based Assessment of Gastrointestinal Injury Score (AGIUS); | — |
Countries
China
Contacts
Public ContactHe Qiulan
First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed