stroke
Conditions
Interventions
Accelerated iTBS group:accelerated iTBS
LF-rTMS group:LF-rTMS
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients clinically diagnosed with first-ever unilateral hemispheric stroke, with MRI or CT confirming hemorrhagic or ischemic stroke, lesion located in one cerebral hemisphere; 2.Age >=18 to =2 weeks and <=6 months; 4.FMA upper limb score < 50; 5.Informed consent obtained from the patient or their guardian.
Exclusion criteria
Exclusion criteria: 1.Brainstem or cerebellar lesions; 2.Severe systemic diseases, cardiac, hepatic, renal diseases, or infectious diseases; 3.History of epilepsy, psychiatric disorders, or other severe emotional dysfunction disorders; 4.Severe cognitive impairment unable to cooperate with assessment and treatment; 5.Intracranial tumors, skull defects, or implants contraindicated for TMS (e.g., cochlear implants, ventriculoperitoneal shunts, etc.); 6.Used drugs that alter cortical excitability within one month.(For example, antiepileptic drugs such as levetiracetam, sodium valproate, carbamazepine, oxcarbazepine, etc., and anti-anxiety/depression drugs such as sertraline hydrochloride tablets, escitalopram oxalate tablets, agomelatine tablets, and duloxetine hydrochloride enteric-coated capsules, etc.); 7.Modified Ashworth Scale score for upper limbs> 3; 8.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Upper Extremity Section of the Fugl-Meyer Assessment, FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wolf motor function test, WMFT;Pinch Strength;Modified Bathel Index,MBI;Rest motor threshold, RMT;Motor evoked potential,MEP;Grip Strength;National Institute of Health Stroke Scale,NIHSS; | — |
Countries
China
Contacts
Public ContactJingming Hou
The First Affiliated Hospital of Army Medical University
Outcome results
None listed