Acute postoperative pain
Conditions
Interventions
Normal saline control group:An equal amount of normal saline was given before the surgical skin incision
Nalbuphine intervention group:0.1mg/kg nalbuphine injection was given before the surgical skin incision
Sponsors
Quzhou People Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for laparoscopic surgery (including appendectomy, cholecystectomy, hernia repair, hysterectomy, renal cystectomy, etc., with an estimated operation time of less than 3 hours); 2. Age: 65 to 85 years old; 3. ASA ? or ? grade; 4. BMI 18~30kg/m^2; 5. Have a clear understanding of and voluntarily participate in this research, and have the informed consent form signed by themselves or their family members.
Exclusion criteria
Exclusion criteria: 1. Patients with mental system disorders who have been taking related medications for a long time; 2. Those with obvious dysfunction of important organs before the operation, bradycardia (heart rate < 50 beats per minute), severe obstructive pulmonary disease, grade III atrioventricular block, and ASA grade III or above; 3. Those who are allergic to or have contraindications to opioid analgesics and other drugs and their components; 4. Long-term use of analgesics, previous history of alcohol addiction, and history of chronic pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS Pain score;The incidence of hypoxia and hypotension during the postoperative recovery period; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia satisfaction;Postoperative cognitive dysfunction score;Ramsay sedation score 30 minutes after extubation;PACU stay time;Incidence of nausea and vomiting;The total amount of sufentanil used within 48 hours and the time of the first analgesia;Postoperative sleep quality;The incidence of postoperative dizziness and drowsiness; | — |
Countries
China
Contacts
Public ContactXiangyu Fang
Quzhou People Hospital
Outcome results
None listed