Perioperative anxiety and depression
Conditions
Interventions
Intervention Arm B:Esketamine 0.3 mg/kg
Intervention Arm A:Esketamine 0.2 mg/kg
Intervention Arm C:Esketamine 0.5 mg/kg
Control Arm D:no intervention measures
Sponsors
Dandong First Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Scheduled for gynecological laparoscopic surgery under general anesthesia. 2. Aged 18–65 years; 3. American Society of Anesthesiologists (ASA) physical status class I-III; 4. Body Mass Index ranging from 18 to 30 kilograms per square meter; 5. Voluntarily participated and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to anesthetic agents; 2. Long-term use of anxiolytic and antidepressant medications; 3. Intracranial hypertension; 4. Presence of psychiatric or language disorders impairing effective communication; 5. Severe hepatic and renal impairment; 6. Severe cardiopulmonary disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Hospital Anxiety and Depression Scale (HADS) scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Recovery;Incidence of Adverse Reactions;Surgical Data;Rescue Analgesia;Numerical Rating Scale Score;QoR-15;Perioperative Hemodynamics; | — |
Countries
China
Contacts
Public ContactWen Chao
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed