Colorectal cancer
Conditions
Interventions
Observation group of MSS/MSI colorectal cancer:None
Sponsors
Jiangsu Second Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Colorectal adenocarcinoma (primary lesion) was confirmed by histopathology; 2.Have confirmed microsatellite status as MSS or MSI (either) in the pathology report or molecular test and can consult the test report; 3.Usable and well-preserved FFPE tissue blocks or unstained sections; 4.The clinical data of the corresponding patients were traceable (including age, gender, date of surgery/harvesting, TNM stage, whether receiving ICI and follow-up outcome); 5.Permission to use samples/data for scientific research has been obtained;
Exclusion criteria
Exclusion criteria: 1.FFPE specimens could not be stained and analyzed for mIF due to poor preservation, massive antigen degradation, section necrosis/insufficient tissue or technical reasons; 2.The histological structure of the specimens was severely damaged and could not represent the original tumor microenvironment; 3.The origin of the specimen is unknown, or the judgment is confused by the combination of other primary tumors; 4.Clinical data were seriously missing to complete the primary analysis or to adjust for confounding factors;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spatial distribution characteristics of the tumor microenvironment and types and proportions of immune cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunotherapy response and follow-up outcomes; | — |
Countries
China
Contacts
Public ContactJin Heiying;Zhang Xiaochun
Jiangsu Second Hospital of Traditional Chinese Medicine
Outcome results
None listed