Patients who undergo painless gastrointestinal endoscopy due to abdominal pain, acid reflux, functional gastrointestinal disease, or physical examination.
Conditions
Interventions
Non-obese group:Based on the endoscopic insertion result of the previous patient, the ciprofol induction dose for the next patient is adjusted after a coin flip opera
Obese group:Based on the endoscopic insertion result of the previous patient, the ciprofol induction dose for the next patient is adjusted after a coin flip opera
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-59 years old; 18.5=28 kg/m^2; 2.Patients with american society of anesthesiologists (ASA) physical status classification ?-?;
Exclusion criteria
Exclusion criteria: 1.Patients who are allergic to sedative and anesthetic drugs such as dexmedetomidine and ciprofol , or allergic to soybeans and eggs. 2.Patients with contraindications to gastrointestinal endoscopy or who refuse to participate in this study. 3.Patients without family members accompanying them. 4.Patients with uncontrolled severe hypertension (systolic blood pressure>=180 mmHg, diastolic blood pressure>=110 mmHg) . 5.Patients with acute coronary syndrome, severe arrhythmia (such as second-degree or third-degree atrioventricular block, sick sinus syndrome, and heart rate < 50 beats per minute), or heart failure. 6.Patients with acute respiratory tract infection, acute exacerbation of bronchial asthma, severe pneumonia, acute exacerbation of chronic obstructive pulmonary disease, or preoperative hypoxemia. 7.Patients with mental health disorders or cognitive impairments who are unable to communicate effectively. 8.History of psychotropic drug or narcotic abuse. 9.Hepatic dysfunction (Child-Pugh Class C or above); renal insufficiency (chronic kidney disease Stage 3 or above). 10.Pregnant women or lactating women. 11.Severe anemia, acute upper gastrointestinal bleeding with shock, pyloric obstruction, achalasia cardia, gastric emptying disorders, and a history of previous upper gastrointestinal surgery. 12.Patients undergoing gastrointestinal polyp treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The optimal induction dose of ciprofol for tolerating gastroscope insertion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep improvement situation;Satisfaction with the anesthesia process;Length of stay in the post-anesthesia care unit;Total dose of ciprofol;Wake up time;Incidence rate of adverse events; | — |
Countries
China
Contacts
Public ContactYu Junma
Hefei First People's Hospital
Outcome results
None listed