Septic shock
Conditions
Interventions
Case Group:None
Control group:None
Sponsors
The First People's Hospital of Lianyungang City
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients clinically diagnosed with septic shock; 2. Age: 18-80 years old, gender not limited; 3. Subjects whose 28-day survival status can be obtained through hospital electronic medical records and other means; 4. Those who have been diagnosed with septic shock and whose maximum blood lactate value is greater than 2mmol/L within 48 hours and have started treatment; 5.For patients in the anisodamine hydrobromide injection group, the maximum daily dosage should not be less than 40mg, and the cumulative dosage should not be less than 80mg.
Exclusion criteria
Exclusion criteria: 1. During hospitalization, the combined use of the following drugs may confuse the evaluation of drug efficacy: atropine, racemic scopolamine; 2. Patients with combined malignant tumors; 3. Patients with combined granulocytopenia; 4. Patients with cardiogenic shock, obstructive shock, and hypovolemic shock; 5. Immunosuppressive patients: Patients who continue to use immunosuppressants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| 7-day all-cause mortality;Blood lactate clearance rate;Blood lactate clearance;Hospital mortality;Sequential Organ Failure Assessment (SOFA);Usage of vasoactive drugs within 7 days;Hemodynamic parameters;Blood indicators: blood routine, blood gas analysis, renal function, liver function, brain natriuretic peptide, infection indicators;Glasgow Coma Scale (GCS;Acute Physiological score;Age score;Chronic Health Evaluation II (APACHE II;Multiple Organ Dysfunction Score (MODS;Acute Gastrointestinal Injury Grading Score (AGI) score; | — |
Countries
China
Contacts
Public ContactKang Xiuwen
The First People's Hospital of Lianyungang City
Outcome results
None listed