Aging
Conditions
Interventions
High-dose treatment group:Intravenous infusion of umbilical cord blood mononuclear cells over a period of 4 months, once per month.
High-dose treatment group:Intravenous infusion of umbilical cord blood mononuclear cells for 2 months, followed by intravenous infusion of normal saline for 2 months, with each infusion occurring once
Control Group:Equal-dose normal saline infusion
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 50 years; 2. No severe diseases in major organs; 3. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals with severe diseases or unstable medical conditions caused by age-related changes in major organs; 2. History of severe allergic reactions; 3. History of malignant tumors or presence of active malignancy; 4. Active systemic or severe focal infections (including HIV and syphilis); 5. Individuals with severe psychiatric disorders or cognitive impairments; 6. Individuals with severe liver or kidney dysfunction, hematologic disorders, or diseases affecting the circulatory, respiratory, or nervous systems (moderate to severe Parkinson’s disease/Alzheimer’s disease); 7. Individuals with any immunodeficiency disease or condition; 8. Patients who, in the investigator's opinion, are unsuitable for participation in the study due to potential protocol violations or any other condition affecting their safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biological age;Comprehensive Geriatric Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement or progression of cardiovascular and cerebrovascular diseases.;Adverse reaction/event occurrence rate;IL-6;Imaging indicators; | — |
Countries
China
Contacts
Public ContactPing Zhu
Chinese PLA General Hospital
Outcome results
None listed