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Mechanistic study on how the kinase domain of TRPM7 mediates histone H3 modifications to promote the growth and metastasis of castration-resistant prostate cancer

Mechanistic study on how the kinase domain of TRPM7 mediates histone H3 modifications to promote the growth and metastasis of castration-resistant prostate cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110694
Enrollment
Unknown
Registered
2025-10-17
Start date
2023-03-30
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate cancer

Interventions

Observation group:None

Sponsors

Third Affiliated Hospital of Sun Yat sen University
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Radical prostatectomy with postoperative pathological confirmation; 2. No radiotherapy or chemotherapy received before surgery.

Exclusion criteria

Exclusion criteria: 1. Patients with a follow-up period of less than 3 years; 2. Paraffin-embedded tissue specimens with incomplete structure.

Design outcomes

Primary

MeasureTime frame
M7CK;H3 phosphorylation;PSA level;Pathological results;Gleason score;Tumor stage;Adjuvant therapy;Biochemical recurrence;Tumor metastasis;Overall survival;Vital signs;—

Secondary

MeasureTime frame
Laboratory indicators;Age;—

Countries

China

Contacts

Public ContactYun Luo

The Third Affiliated Hospital of Sun Yat-sen University

luoyun8@mail.sysu.edu.cn+86 135 6018 9936

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026