Chronic pain combined with depression
Conditions
Interventions
Trigeminal neuralgia combined with depression group:None
Trigeminal neuralgia without depression group:None
Healthy control group:None
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with classical trigeminal neuralgia according to the International Headache Society diagnostic criteria. 2. Age >= 18 years. 3. Provided written informed consent for the pre-operative assessment, intra-operative sampling, and post-operative follow-up. 4. No history of prior surgical interventions for trigeminal neuralgia, including percutaneous ganglion ablation (such as balloon Compression or radiofrequency thermocoagulation), stereotactic radiosurgery, or microvascular decompression etc..
Exclusion criteria
Exclusion criteria: 1. History of stroke, intracranial hemorrhage, brain tumor, severe traumatic brain injury, epilepsy, or neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease). 2. History of schizophrenia, bipolar disorder, or anxiety/depressive disorders that preceded the onset of trigeminal neuralgia. 3. Use of medications including sedative-hypnotics, diuretics, antidepressants, or glucocorticoids within the past 3 months. 4. Presence of severe systemic diseases (e.g., hepatic or renal insufficiency, advanced cancer). 5. Pregnancy or lactation. 6. Alcohol abuse. 7. History of substance abuse or dependence within the past 3 months. 8. Any contraindication to magnetic resonance imaging (MRI) or inability to complete the brain MRI scan due to excessive movement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diffusion tensor imaging along perivascular spaces Index;Cerebrospinal fluid urea concentration;Resting-State Functional MRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Enlarged Perivascular Space Score;Cerebrospinal fluid metabolites;Blood metabolites;Blood urea concentration;Hamilton Depression Rating Scale score;Pittsburgh Sleep Quality Index Scale score;Ascertain Dementia 8 Scale score;Brief Pain Inventory Scale score;Visual Analogue Scale score; | — |
Countries
China
Contacts
Public ContactHuang Changsheng
Xiangya Hospital of Central South University
Outcome results
None listed