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Effectiveness and safety of glucose-lowering drugs as an adjunct to insulin therapy in Chinese patients with type 1 diabetes: a retrospective, observational study

Effectiveness and safety of glucose-lowering drugs as an adjunct to insulin therapy in Chinese patients with type 1 diabetes: a retrospective, observational study

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110682
Enrollment
Unknown
Registered
2025-10-17
Start date
2025-10-20
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 1 diabetes

Interventions

Group of glucose-lowering drugs (GLDs) as an adjunct to insulin:None
Insulin group:None

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.The research group consists of T1DM patients who first used oral hypoglycemic drugs from January 2013 to June 2024 and had a glycated hemoglobin level of >= 7%; The control group consisted of T1DM patients who maintained only insulin treatment regimen and had glycated hemoglobin >= 7%; 2.Age >= 18 years old; 3.At least one recorded HbA1c value before the start of treatment; 4.Maintain medication regimen as needed from baseline to at least 3 months; 5.Record the first glycated hemoglobin value after treatment.

Exclusion criteria

Exclusion criteria: 1.The patient had already used hypoglycemic drugs as an adjunct to insulin therapy before admission; 2.DKA? Serious infection, perioperative status, severe trauma, pregnancy, patient's past or current involvement in interventional clinical research; 3.The standard for determining stress hyperglycemia by the supervising physician; 4.Patients who have no medication records or have not followed the treatment plan formulated by the doctor.

Design outcomes

Primary

MeasureTime frame
HbA1c;Absolute and relative insulin doses;

Countries

China

Contacts

Public ContactShi Chenyang

Shanghai General Hospital

shicheny@163.com+86 21 3612 3596

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026