Acute Ischemic Stroke
Conditions
Interventions
Mechanical Thrombectomy Group:NA
Sponsors
The Second Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients meeting all of the following criteria will be included in the study: 1. Age >= 18 years. 2. Clinical diagnosis of acute ischemic stroke (AIS) with a clearly defined time of onset. 3. Confirmed intracranial large vessel occlusion (LVO) by vascular imaging (e.g., CT angiography (CTA), MR angiography (MRA), or digital subtraction angiography (DSA)), including but not limited to terminal internal carotid artery (ICA), middle cerebral artery (MCA) M1 or M2 segments, intracranial vertebral artery (VA), or basilar artery (BA) occlusion. 4. Underwent endovascular mechanical thrombectomy within a specified time window (the specific window will be based on contemporary clinical guidelines and standards of practice). 5. Angiographic assessment immediately post-procedure or within 24 hours shows successful recanalization of the target vessel, defined as a modified Thrombolysis In Cerebral Infarction (mTICI) grade of 2b or 3. 6. Patients treated at the Department of Neurosurgery, Second Affiliated Hospital, Zhejiang University School of Medicine, between 2016 and 2023. 7. Availability of relatively complete baseline clinical data, laboratory findings, imaging results, procedural records, and 90-day modified Rankin Scale (mRS) score follow-up data for analysis.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will be excluded from the study: 1. Post-mechanical thrombectomy angiographic assessment showing failure to achieve successful recanalization of the target vessel (i.e., mTICI grade 0, 1, or 2a). 2. Missing or unobtainable 90-day modified Rankin Scale (mRS) score. 3. Etiology of the current acute ischemic stroke is not primary intracranial large vessel occlusion, such as low cerebral perfusion due to the mass effect of a significant intracerebral hemorrhage (ICH), direct vascular compression by an intracranial space-occupying lesion (e.g., tumor, abscess), or carcinomatous meningitis. 4. Receipt of non-standard or experimental neuroprotective therapies before or during mechanical thrombectomy that could significantly confound the assessment of neurological outcome. 5. Pre-existing severe neurological disability (e.g., pre-stroke modified Rankin Scale score of 4 or 5) that would make it difficult for the 90-day mRS assessment to accurately reflect the true impact of the current stroke event (Note: the protocol mentions collecting history of prior stroke; specific exclusion would depend on the degree of disability from prior stroke). 6. Critical baseline data, imaging data (such as pre-procedural ASPECTS or other key imaging markers), or procedural records are substantially missing, precluding effective risk factor analysis and model development. 7. Extremely limited life expectancy (e.g., due to advanced malignancy or other end-stage diseases, with an anticipated survival of < 3 months), where the 90-day functional outcome would be predominantly determined by the underlying primary condition. 8. Concurrent participation in other clinical studies that could substantially interfere with the primary outcome measure of this study (90-day mRS score).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Rankin Scale score;Futile Recanalization Rate at 90 Days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality at 90 days;Symptomatic Intracranial Hemorrhage; | — |
Countries
China
Contacts
Public ContactJianru Li
Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed