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Clinical effect of cerebellar parietal nuclear electrical stimulation combined with transcutaneous vagus nerve stimulation on consciousness impairment in patients with vegetative state

Clinical effect of cerebellar parietal nuclear electrical stimulation combined with transcutaneous vagus nerve stimulation on consciousness impairment in patients with vegetative state

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500110655
Enrollment
Unknown
Registered
2025-10-17
Start date
2025-10-27
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disturbance of consciousness

Interventions

Treatment group A received FNS stimulation:On the basis of conventional treatment, cerebellar fast neuromodulation stimulation (FNS) was added. The FNS electrodes were placed on the skin of both masto
each session lasted 20 minutes, once a day, for 30 days as one course of treatment, with a total of two courses.
Treatment group B received tVNS stimulation:On the basis of conventional treatment, transcutaneous vagus nerve stimulation (tVNS) is added. The earplug electrode of the auricular vagus nerve therapy d
Treatment group c received FNS tVNS stimulation:On the basis of conventional treatment, cerebellar fast neuromodulation stimulation (FNS) and transcutaneous vagus nerve stimulation (tVNS) were added.
each session lasted for 20 minutes, once a day, for 30 days as one course of treatment, with a total of two courses. The ear canal electrode of the ear vagus nerve treatment instrument was fixed in th

Sponsors

Yantai Affiliated Hospital of Binzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of PVS; 2. Age 18-80 years old; 3.First appearance of PVS; 4.PVS lasts more than 1 month; 5.The patient's family allows the patient to participate in this study, cooperate with the doctor's treatment, and allow the collection and measurement of indicators; 6.Have family members or authorized personnel sign the informed consent form for inclusion in this study.

Exclusion criteria

Exclusion criteria: 1.Fever, electrolyte disturbance, and unstable vital signs; 2.Have advanced malignant tumors or have received radiotherapy or chemotherapy in the previous 6 months; 3.Implanted with implantable electronic devices (such as pacemakers); 4.Intracranial metal implants; 5.in pregnancy; 6.Local skin lesions or inflammation; 7.Increased intracranial pressure; 8.Suffering from severe heart disease; 9.Experienced acute large-scale cerebral infarction; 10.Implanted devices containing metal parts in the treatment area.

Design outcomes

Primary

MeasureTime frame
Brainstem Auditory Evoked Potentials (BAEPs);Glasgow Coma Scale (GCS);

Countries

China

Contacts

Public ContactSun Fangfei

Yantai Affiliated Hospital of Binzhou Medical University

912857695@qq.com+86 133 6535 2891

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026