Perioperative analgesia
Conditions
Interventions
Oseltamivir group:Administer oliceridine 0.02 mg/kg for induction, with intraoperative analgesic supplementation via 0.01 mg/kg bolus doses.
Sufentanil group:Administer sufentanil 0.2ug/kg for induction, with intraoperative analgesic supplementation via 0.1ug/kg bolus doses.
Sponsors
Anesthesiology department, Affiliated Women and Children's Medical Center of Guangzhou Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18-55 years; 2. ASA physical status classification I-II; 3. Provision of signed informed consent for both anesthesia consent and clinical research consent.
Exclusion criteria
Exclusion criteria: 1. Patient withdrawal of consent for study participation; 2. Body mass index (BMI) >30 kg/m^2; 3. Allergy to any investigational drugs involved in this study; 4. Contraindications to rectus sheath plane block; 5. Preoperative hepatic or renal dysfunction; 6. Preoperative coagulation abnormalities; 7. Elevated preoperative infection markers; 8. Chronic cardiovascular diseases (e.g., hypertension, coronary artery disease); 9. Chronic respiratory diseases (e.g., COPD, asthma); 10. Endocrine disorders (e.g., diabetes mellitus, thyroid dysfunction); 11. Other conditions precluding ambulatory surgical pathway enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cardiovascular depressive events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting (PONV;Rescue analgesic dosage;Postoperative NRS value; | — |
Countries
China
Contacts
Public ContactBolun Wen
Anesthesiology department, Affiliated Women and Children's Medical Center of Guangzhou Medical University
Outcome results
None listed