Degenerative diseases of the lumbar spine
Conditions
Interventions
Sponsors
West China Tianfu Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who need lumbar TLIF surgery for giant disc herniation, recurrent disc herniation, intervertebral pseudoarthrosis, symptomatic lumbar spondylolisthesis, etc; 2. The patient is >=18 years old and <=80 years old; 3. The patient does not have any congenital disease; 4. The patient does not have any blood system disease; 5. Patients agree to participate in this study and sign the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are not suitable for lumbar TLIF surgery because of extensive epidural scarring, arachnoiditis, active infection, nerve root degeneration, or severe osteoporosis; 2. Patients are allergic to TXA; 3. Patients with liver or kidney insufficiency; 4. Patients with history of thrombosis; 5. The patient is younger than 18 years old or older than 80 years old; 6. Patients with severe cardiovascular and cerebrovascular and other underlying diseases that are not suitable for surgery; 7. Patients with intraoperative dural injury that produces cerebrospinal fluid leakage; 8. Patients and their families refused to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of postoperative nausea and vomiting following tranexamic acid infusion administered 6 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrolyte profile (sodium potassium magnesium calcium chloride);Postoperative blood loss;Hospitalisation satisfaction;Incidence of VTE;Postoperative drainage;Length of Hospital Stay;Fibrinolysis Markers; | — |
Countries
China
Contacts
Public ContactLiu Li
Sichuan University West China Tianfu Hospital
Outcome results
None listed