orthopedic knee replacement surgery
Conditions
Interventions
Control group (Sufentanil group):Control group: Loading dose: 7.5µg of sufentanil was intravenously injected. After 10 minutes of loading dose, 48-hour PCIA was initiated. 2.5µg/kg was mixed with norm
Experimental group (Othelidine group):Experimental group: Loading dose: Intravenous injection of oxelidine 1.5mg. After 10 minutes of loading dose, 48-hour PCIA was initiated. 0.5mg/kg was mixed with
Sponsors
The Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for orthopedic knee replacement surgery; 2. Age: 60-75 years old, gender not limited; 3. ASA classification grades I - III; 4. BMI 18-30kg / m^2; 5. Normal preoperative cognitive function can cooperate with subsequent studies and scale evaluations; 6. Agree to apply the postoperative analgesic pump.
Exclusion criteria
Exclusion criteria: 1. There were already other acute or chronic pains before the operation; 2. Advanced tumors with ascites or extensive metastasis, or those undergoing systemic chemotherapy or radiotherapy, or requiring hyperthermic perfusion after surgery; 3. There is severe liver and kidney dysfunction as well as coagulation disorders; 4. Allergic to or contraindicated to the anesthetics, adjuvant analgesics, remedial analgesics, antiemetic drugs and antibiotics used in the study; 5. Long-term opioid treatment or the use of any analgesics within 48 hours before the operation; Suffer from sleep apnea syndrome; 6. Suffering from mental and neurological disorders, gastrointestinal obstruction, chronic obstructive pulmonary disease or pulmonary heart disease, cardiovascular diseases, etc; 7. Oral, inhaled or parenteral injection of corticosteroids should be administered within 3 months before the operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of respiratory depression;Postoperative adverse events;Postoperative hemodynamic manifestations such as heart rate and blood pressure;Sedation score and adverse respiratory events;Quality of Recovery-15 (QoR-15);Postoperative remedial analgesia conditions: the time of the first remedial analgesia, the number of remedial analgesia within 48 hours, and the total amount of remedial analgesia drugs;The incidence of nausea and vomiting;Time to first defecation postoperatively: The time interval from the end of surgery to the first defecation;Time to first ambulation postoperatively: The time from the end of surgery to the first ambulation;Length of hospital stay: Number of days from hospital admission to discharge;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactWang Xiuli
The Third Hospital of Hebei Medical University
Outcome results
None listed