lung cancer
Conditions
Interventions
sufentanil group:sufentanil 2.0µg/kg, diluted to 100 ml with normal saline, loading volume 2 ml, background infusion rate 1ml/h, lockout time 15 min
Oliceridine group:Oliceridine at a dose of 0.6 mg/kg was diluted to 100 ml with normal saline. The loading dose was 2 ml, the background infusion rate was 1 ml/h, and the lockout time was 15 min.
Oliceridine + Sufentanil group:Oliceridine 0.3 mg/kg + Sufentanil 1.0 µg/kg, diluted to 100 ml with normal saline. The loading dose is 2 ml, the background infusion rate is 1 ml/h, and the lockout tim
Sponsors
Tianjin Cancer Hospital Airport Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old, ASA class I-III, BMI18-30kg/m^2; 2. Diagnosis confirmed and requiring unilateral thoracoscopic pneumonectomy (including pulmonary wedge resection, pulmonary segmentectomy, lobectomy and radical resection of lung cancer); 3. Good cardiopulmonary function without surgical contraindications; 4. Informed consent and voluntary participation.
Exclusion criteria
Exclusion criteria: 1. Participation in other clinical trials in recent 3 months; 2. Non-cooperation or withdrawal during the study; 3. American Society of Anesthesiologists (ASA) classification> III; 4. Severe cardiovascular and cerebrovascular diseases; 5. Significant abnormal liver and kidney function; 6. Pulmonary infection; 7. Increased intracranial pressure; 8. Inadequately controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure greater than 180/100 mmHg, 1mmHg=0.133 kPa); 9. History of digestive tract ulcers or bleeding; 10. Tendency to bleed; 11. Hyperthyroidism; 12. Recurrent pulmonary hypertension; 13. Speech disorders or psychiatric disorders; 14. History of long-term opioid use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe pain (NRS >=4 during coughing) within 48 hours after surgery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative recovery status;NRS pain scores at 4 hours after surgery, on postoperative day 1 (POD 1), and on postoperative day 2 (POD 2);Number of postoperative rescue analgesia times;Record the occurrence of adverse reactions in patients.;Effective pressing times of the analgesia pump within 48 hours after surgery;QoR scores of POD1 and POD2; | — |
Countries
China
Contacts
Public ContactZhang Peng
Tianjin Cancer Hospital Airport Hospital
Outcome results
None listed