Mild cognitive impairment
Conditions
Interventions
Intervention group:Eye-tracking-based cognitive training plus routine care
Control group:Routine care
Sponsors
Guangzhou Geriatric Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: Based on the diagnostic criteria for Mild Cognitive Impairment (MCI) as described in the American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) published in 2013; 2: Aged 50 to 75; 3: Simplified Mental Status Check Score: 18–26 points; 4: Montreal Cognitive Assessment Scale Score: 18–26 points; 5: Clinical Dementia Rating Scale score of 0.5 points/at least 0.5 points in the memory domain; 6: The Frontal Function Scale assesses subjects' cognitive function; the FAB total score is 18 points, with scores below 12 indicating abnormal frontal lobe function, where lower scores denote poorer outcomes. 7: Barthel Index and IADL Scale for assessing functional ability in activities of daily living:Score 0.4, with no history of blurred vision, double vision, cataract surgery, or other ocular procedures, and were not taking anticholinergic medications affecting eye movements; 10: Sign the informed consent form and voluntarily participate.
Exclusion criteria
Exclusion criteria: 1: Severe cognitive impairment; 2: There exists a clear history of other primary causes impairing cognition, such as cerebral infarction or cerebral haemorrhage; cognitive impairment arising from conditions including traumatic brain injury, hydrocephalus, epileptic seizures, extrapyramidal disorders, autoimmune encephalopathies and paraneoplastic syndromes, or infectious diseases; 3: Excluding those suffering from anxiety, depression, or psychosis, or those taking psychiatric medication on a long-term basis; 4: Conduct clinical diagnostic interviews with participants and, where applicable, their relatives to rule out dementia. Use the MoCA to screen for cognitive impairment, excluding cases of dementia or participants with a MoCA score <17; 5: Subjects exhibiting severe motion artefact interference during fNIRS data analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fNIRS metrics: Oxyhaemoglobin levels in the frontal-temporal cortex during executive function tasks and functional connectivity within brain regions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioural indicators;Eye movement metrics;Neuropsychological assessment; | — |
Countries
China
Contacts
Public ContactSong Chengxian
Guangzhou Geriatric Hospital
Outcome results
None listed