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Long-term Prognosis of Thymectomy Versus Conservative Treatment in AChR-Ab–Positive Myasthenia Gravis: A Multicenter Retrospective Study in China

Long-term Prognosis of Thymectomy Versus Conservative Treatment in AChR-Ab–Positive Myasthenia Gravis: A Multicenter Retrospective Study in China

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110600
Enrollment
Unknown
Registered
2025-10-16
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myasthenia gravis

Interventions

Thymectomy Acceptance Group:None
Control group:None

Sponsors

Shijiazhuang People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. There is no age limit, male or female; 2. Diagnosis of myasthenia gravis, based on the typical clinical features of MG (fluctuating myasthenia), the diagnosis can be made by meeting any of the following 3 points (1) History of abnormal neuromuscular transmission confirmed by single-fiber electromyography or repetitive nerve stimulation; (2) history of positive neostigmine test; (3) Positive serological test of AchR antibody (detection method: RIA and CBA); 3. Complete clinical data.

Exclusion criteria

Exclusion criteria: 1. Patients with thymoma and MG. 2. Concomitant psychiatric illness or family history; 3. History of other malignant tumors other than thymoma.

Design outcomes

Primary

MeasureTime frame
Proportion of Patients Achieving Optimal Postintervention Status (PIS) at 5-Year Post-Treatment: Thymectomy vs. Conservative Management;

Secondary

MeasureTime frame
Proportion of Patients Achieving Optimal Postintervention Status (PIS) at 5-Year Post-Treatment: Thymectomy vs. Conservative Management;Optimal Postintervention Status (PIS) Rates at 5 Years in Ocular Myasthenia Gravis Patients: Thymectomy vs. Conservative Management;

Countries

China

Contacts

Public ContactQi Guoyan

Shijiazhuang People’s Hospital

qiguoyan1106@sina.com+86 176 0311 9295

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026