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Clinical study on improvement of remifentanil induced hyperalgesia by intracavitary low dose esketamine

Clinical study on improvement of remifentanil induced hyperalgesia by intracavitary low dose esketamine

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500110594
Enrollment
Unknown
Registered
2025-10-16
Start date
2025-11-01
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gallbladder inflammation, gallstones

Interventions

Control group:Physiological saline (same dose)
Experimental group:escalodine, 0.25mg /kg/ h

Sponsors

Shanghai East Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for laparoscopic cholecystectomy; 2. ASA classification I-II, aged 18-80 years; 3. Patients are healthy with no other congenital diseases; 4. Patients voluntarily sign the informed consent form; 5. No allergy to the trial medication; 6. Patients receive the trial medication with good compliance.

Exclusion criteria

Exclusion criteria: 1. Patients with severe neuropsychiatric disorders who cannot cooperate; 2. Patients with serious illnesses (heart, lung, brain, kidney, etc.); 3. Patients with recent respiratory infections; 4. Patients allergic to the investigational drug; 5. Participants explicitly refusing to participate in this study; 6. Minors, pregnant women, or those in pregnancy; 7. Patients undergoing non-primary cholecystectomy; 8. Patients with severe .

Design outcomes

Primary

MeasureTime frame
Visual analogue scale;

Secondary

MeasureTime frame
Pittsburgh Sleep Quality Index Score;quality of recovery-40 questionnaire Score;Self-Rating Anxiety Scale Score;Pain threshold;

Countries

China

Contacts

Public ContactQi Shiyuan

Shanghai East Hospital

qishiyuan98@163.com+86 139 9806 1326

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026