Ishemic stroke
Conditions
Interventions
Intervention Group:Use a non-invasive transcutaneous auricular vagus nerve stimulator to stimulate the main distribution areas of the auricular vagal branches, anatomically localized to the concha and
earlobe electrodes are securely fixed bilaterally over the vagal nerve distribution areas in the concha, and the device is powered on. Set the stimulation waveform to a dense-sparse pattern at 4/20 Hz
all other treatments follow specialty guidelines.
Control Group:The procedure is identical to that of the intervention group, except that no stimulation is delivered. No additional brain stimulation therapies will be administered, and all other treat
Sponsors
Xindu District People’s Hospital of Chengdu
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–80 years, with symptom onset within 24 hours; 2. Diagnosis of acute ischemic stroke according to the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke (2023), with an NIHSS score >=8; 3. Informed consent signed by the patient and/or legal representative.
Exclusion criteria
Exclusion criteria: 1. Newly developed pulmonary infection or recent craniocerebral trauma; 2. Presence of severe neurological disorders, including epilepsy, encephalitis, or moderate-to-severe dementia; 3. Severe cardiac, hepatic, or renal dysfunction; patients in the terminal stage of disease; patients with malignancies or severe hematological disorders; or those with acute myocardial infarction; 4. Special populations, such as pregnant patients; 5. Patients with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of SAP ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pneumonia Severity Index;Heart rate variability (HRV; Blood pressure variability (BPV) ; Skin adverse reactions ;Inflammatory markers (Serum IL-6, TNF-a, C-reactive protein, procalcitonin, and routine blood tests);Proteomic analysis of blood samples and single-cell sequencing of bronchoalveolar lavage fluid (if necessary); | — |
Countries
China
Contacts
Public ContactZhang Jun
Xindu District People’s Hospital of Chengdu
Outcome results
None listed