Thyroid Diseases
Conditions
Interventions
Group K: S-ketamine is administered orally before the induction of anesthesia.
Group C:Volume-matched glucose solution is administered orally before the induction of anesthesia.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent form; 2.Aged 18-75 years; 3.American Society of Anesthesiologists ASA I - ?; 4.BMI :18-30 kg/m^2; 5.Patients undergoing elective thyroid surgery;
Exclusion criteria
Exclusion criteria: 1.patients with severe hepatic , renal , neurological , or cardiovascular diseases ; 2.Patients with chronic pharyngitis and chronic bronchitis ; 3.A preoperative history of respiratory infection or throat pain ; 4. Patients with pre-operative neuropsychiatric disorders (e.g. , Schizophrenia , Epilepsy , Parkinson's Disease , and a History of Delirium) ; 5.Patients with communication disorders; 6.Patients with Substance Use Disorder ; 7.Unsuccessful first attempt at intubation; 8.Patients with cervical spondylosis; 9.Patients with contraindications to S-ketamine(e.g. , hypersensitivity to its components , hyperthyroidism , glaucoma , or uncontrolled hypertension) ; 10.Patients with diabetes mellitus ;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sore throat; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative throat pain;The severity of postoperative sore throat ;The incidence of postoperative hoarseness;The VAS scores ;Quality of recovery on postoperative Day 1;Sleep quality scores ;Anxiety and depression scores ;Intraoperative Data;The incidence of cough during extubation ;Baseline Demographic Data;Consumption of flurbiprofen axetil and sufentanil in the Post-anesthetic care unit; | — |
Countries
China
Contacts
Public ContactGuanghong Xu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed