epidural related materna fever
Conditions
Interventions
Group Sufentanil :0.5 µg/mL sufentanil and 0.075%ropivacaine for labor analgesia
Group Dexmedetomidine:0.25 µg/mL Dexmedetomidine, 0.25 µg/mL Sufentanil, and 0.075% Ropivacaine for Labor Analgesia.
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ASA Physical Status II -III; 2. Gestational age >=37 weeks; 3. Age >= 18 year; 4. Primiparous singleton pregnancies; 5. Planned to undergoing epidural labor analgesia.
Exclusion criteria
Exclusion criteria: 1.Contraindications to neuraxial anesthesia (e.g., coagulation disorders, , central nervous system diseases, etc.); 2. Body temperature >=37.5? at admission; 3. Group B Streptococcus (GBS) positive or other systemic infections; 4. Stillbirth; 5. Rupture of membranes >=6 hours; 6. Receipt of opioid or sedative medications within 4 hours prior to labor analgesia; 7. Allergy to sufentanyl, dexmedetomidine, or ropivacaine; 8. Inability to cooperate wiht the study for any reason; 9. Participation in other clinical trials within the 1 week prior to study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The maternal fever rate during labor analgesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hourly maternal tympanic temperature;NRS scores at hourly intervals before (baseline) and after the initiation of labor analgesia until delivery;Sensory block level during labor analgesia;Motor block assessed by Modified Bromage Scale during labor analgesia;Intrapartum cesarean delivery rate during labor analgesia;Incidence of postpartum hemorrhage (PPH) within 24 hours after delivery;Time to first breastfeeding postpartum;Length of postpartum hospital stay;Incidence of maternal complications within 42 days postpartum;Neonatal Apgar score;NICU admission rate; | — |
Countries
China
Contacts
Public ContactShuangqiong Zhou
Shanghai First Maternity and Infant Hospital
Outcome results
None listed