Severe extensive burns
Conditions
Interventions
Group A:Pre-flushed normal saline pulse positive-pressure flushing
Group B:Heparinized saline (9.375U/ml) pulse positive-pressure flushing
Group C:Heparinized saline (62.5U/ml) pulse positive-pressure locking
Sponsors
Weifang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18 to 65 years; (2) Burn area 30% TBSA to 95% TBSA; (3) Patients receiving intravenous therapy via CVC (Central Venous Catheter); (4) Expected catheter indwelling time >=7 days.
Exclusion criteria
Exclusion criteria: (1) Patients requiring continuous fluid infusion without the need for catheter locking; (2) Patients with a history of heparin allergy; (3) Patients with severe bleeding tendency or coagulation disorders; (4) Patients diagnosed with venous thromboembolism (VTE); (5) Poorly compliant patients; (6) Patients with allergies to catheters, port devices, or related medical equipment; (7) Patients with cardiac dysfunction; (8) Deceased patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Catheter patency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of intraluminal thrombosis;Catheter-related infection;Comparison of coagulation parameters; | — |
Countries
China
Contacts
Public ContactWang Hui
Shandong Second Medical University; Weifang People's Hospital
Outcome results
None listed