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Comparison of posterior-oblique tibial osteotomy(PTO) and opening-wedge high tibial osteotomy(OW-HTO) for medial compartment osteoarthritis of the knee

Comparison of posterior-oblique tibial osteotomy(PTO) and opening-wedge high tibial osteotomy(OW-HTO) for medial compartment osteoarthritis of the knee

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500110550
Enrollment
Unknown
Registered
2025-10-15
Start date
2025-10-17
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medial compartment osteoarthritis of the knee

Interventions

Posterior-oblique tibial osteotomy group:Posterior-oblique tibial osteotomy:After making a 5-6 cm medial skin incision on the lower leg, dissect downward through the fat to expose the fascial layer o
Opening-wedge high tibial osteotomy group:Opening-wedge high tibial osteotomy: After making a 5–6 cm medial skin incision on the lower leg, dissect downward through the fat to expose the fascial layer

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.The patient is aged between 45 and 80 years old; 2.Medial compartment osteoarthritis (OA) of the knee joint (diagnostic criteria - medial joint pain, limited daily walking function, medial joint tenderness, grade 4 degeneration of medial cartilage on MRI) combined with varus deformity of the knee joint >= 5°; 3. Conservative treatment has been ineffective for half a year

Exclusion criteria

Exclusion criteria: 1.Degeneration of the lateral compartment cartilage to grade 3 or above; 2. Knee extension limitation >=10°; 3.Range of motion =30; 5.Knee joint instability (excluding lateral laxity of the knee joint without a history of trauma); 6. Smoking patients; 7. Inflammatory arthritis; 8. The contribution to varus on the femoral side is>=5° (with the angle formed by the mechanical axis of the femoral side and the tangent of the two condyles - the mechanical angle of the lateral distal femur, mLFDA, set at 90° as the normal standard, and any angle exceeding 95° needs to be excluded); 9.Trauma and previous history of knee joint surgery. 10.Refusal to sign the informed consent form due to refusal to undergo randomization or follow-up 11.Unable to independently provide informed consent and unable to comprehend the follow-up scoring scale.

Design outcomes

Primary

MeasureTime frame
Patient-Reported Outcome Score (KOOS);

Secondary

MeasureTime frame
Visual Analogue Scale;Western Ontario and McMaster Universities Osteoarthritis Index;Lysholm Knee Score;Full-length weight-bearing lower limb alignment radiograph;Computed Tomography image of knee;Magnetic Resonance Imaging of knee;Physical examination(knee range of motion );Arthroscopy examination;Incidence of complications;

Countries

China

Contacts

Public ContactZhao Jinzhong

Shanghai Sixth People's Hospital

jzzhao@sjtu.edu.cn+86 189 3017 7160

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026